Diisocyanates are a family of substances used to make polyurethane products that people rely on for modern comforts and technologies. There are two primary diisocyanates: toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI).

Toluene diisocyanate (TDI) is mainly used for flexible polyurethane foam that can be found in a wide range of everyday products including furniture, bedding, carpet underlay and packaging. TDI is also used in the manufacture of coatings, sealants, adhesives and elastomers. TDI produces lighter automobile parts, saving weight, and making vehicles more energy efficient.

Methylenediphenyl diisocyanate (MDI) is used primarily for rigid polyurethane foams such as insulation, coatings, adhesives, sealants, and elastomers used in paints, glues, weather resistant materials, and footwear. MDI is also used as a binder for wood and to produce mold cores for the foundry industry. Insulation made with MDI helps save heating and cooling costs and conserves energy.

The American Chemistry Council (ACC) Diisocyanates Panel was established in 1988 and consists of the major U.S. producers of MDI and/or TDI. The Panel monitors impending regulatory and legislative actions affecting the production or use of TDI and MDI and develops scientifically sound research and advocacy to address health, safety and environmental issues. The Panel is guided by the principles of Responsible Care®.